I went to college when I was 16, dropped out a year later and was working. When i met my husband, our first date was my 18th birthday; he was 42. We were married 6 months later; that was 31 years ago. Now, let me preface by saying, I love my husband, I adore him, and I do not regret marrying him. 
 
However.... 
 
Can a marriage with this age gap work? Clearly, it can. However, I can assure it, if marriage is difficult, having this large of an age difference increases the problems significantly. There are a 1000 little issues that can cause friction that are directly attributed to the difference in our ages.  
Fortunately, there are no childen involved, or I believe it would have been even more difficult.  
 
In addition to the differences that simply occur because the two of you grow up with completely different life experiences, there is also the hard cold fact that the bodies are aging at different rates. My husband is in good shape for a 73 year old man, but he is _73_; he simply does not have the strength, energy, or desire to do things we once did, and the memory begins to slip as well. I understand that. But its not easy, I'm 49, and there are things I would like to do, things I would like him to do, and the reality of it is, he's simply not physically up to it. I love being with him at home more than I would enjoy going antiquing or to an event on the weekends.  
 
Are you strong enough to stand up to be different? We also think its hilarious when someone looks at us and then mention, your father or your daughter, and we correct them, to 'my spouse'. People are shocked and embarassed, others will feel its perfectly okay to tell you what you are doing is wrong. if you want to blend in, being with a significantly older person is not the way to do it. 
 
Can you separate the spouse from an authority figure? We are taught to respect our elders, etc. Now you are married to one. Just because he's older, doesn't make him right. Are you strong enough to be able to see this individual as a man who is a partner, not someone who is a father? And you will most likely have to teach him not to treat you like a child. 
 
Are you prepared to give up your youth for an older man? Life is not a rehearsal, this is your one shot. Are you willing to stay with this person, and not date other people, party, go to college spring break, etc. while your friends do? its very hard in a college environment not to want to hang with people your own age, if you do, you risk destroying your relationship. 
 
Are you prepared for the possibility that you may have to nurse your husband in his final days? True, spouses get sick at any age, but with someone that much older, you must be prepared for this eventuality.  
 
Are you prepared to be alone and independent? My husband insisted I complete my education, The day I graduated with my masters, I gave HIM a gold watch, he could retire from all the hard work he labored to get me thru school. He wanted me to be able to fend for myself when he is gone. 
 
Are you prepared to make financial and purchasing decisions on your own? When my car died, my husband drove me to the dealership and said, okay, buy yourself a car. I told him, I couldn't do it,, and he said to me, you will have to do it sooner or later, best to do it sooner. And so I did. I have managed the money, major purchases, investments, etc. for the past 31 years, again, in preparation of the day that I will be alone. 
 
Are you both prepared for the day you no longer need him? Its a terrifying turn of events, the day you no longer need the person you leaned on for so many years. It requires a great deal of trust and commitment on both sides: first, that the investment and trust the spouse makes will not betrayed, and secondly, that the newly independent spouse isn't going to simply go wild with this new way of life. 
 
Both parties need to really consider what the future brings... first you fall in lust, then you fall out of lust and into love, that's when the hard work starts.